2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (512):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-175359
    USP7-IN-19
    USP7-IN-19 is a USP7 inhibitor. USP7-IN-19 can be used for synthesis of PROTAC USP7 Degrader-1 (HY-175358).
    USP7-IN-19
  • HY-46340
    AZD9496 deacrylic acid phenol 2173404-70-9
    AZD9496 deacrylic acid phenol is a fragment of target protein ligand of PROTAC ER Degrader-4 (HY-135309).
    AZD9496 deacrylic acid phenol
  • HY-186118
    TEAD ligand 6
    TEAD ligand 6 is a TEAD ligand. TEAD ligand 6 serves as a ligand for target protein for PROTAC (Ligands for Target Protein for PROTAC) and is used to develop and design PROTAC-based TEAD degraders, such as KG-FP-003 (HY-186117). TEAD ligand 6 applies to glioblastoma research.
    TEAD ligand 6
  • HY-183729
    RET-IN-34 2222758-09-8
    RET-IN-34 (Compound EV1) is a RET inhibitor with an IC50 of 0.89 nM. RET-IN-34 serves as a target protein ligand for PROTAC synthesis (Ligand for Target Protein for PROTAC). RET-IN-34 is applicable for the synthesis of PROTAC RET Degrader 2 (HY-183783). RET-IN-34 exhibits anticancer activity against medullary thyroid carcinoma. RET-IN-34 can be used in studies related to medullary thyroid carcinoma.
    RET-IN-34
  • HY-168248
    BRM/BRG1 ligand 2 2933125-88-1
    BRM/BRG1 ligand 2 is the ligand for target protein, which can be used for synthesis of PROTAC BRM/BRG1 degrader-2 (HY-168247).
    BRM/BRG1 ligand 2
  • HY-175543
    BTK ligand 16
    BTK ligand 16 is a BTK ligand that can be used for synthesis of TQ-3959 (HY-175541).
    BTK ligand 16
  • HY-141486A
    PROTAC PARP/EGFR ligand 1 2661609-57-8
    PROTAC PARP/EGFR ligand 1 is an active compound that can be used for the synthesis of dual PARP EGFR degraders by proteolytic targeting chimera (PROTAC) technology.
    PROTAC PARP/EGFR ligand 1
  • HY-177379
    EGFR ligand-14 1792968-00-3
    EGFR ligand-14 is an EGFR ligand. EGFR ligand-14 can be used for the synthesis of SJF-1521 (HY-131865).
    EGFR ligand-14
  • HY-400666A
    AR ligand-44 TFA
    AR ligand-44 TFA is an androgen receptor ligand that can be used in the synthesis of PROTACs, such as ARD-2051 (HY-149862).
    AR ligand-44 TFA
  • HY-183996
    PHD-1 ligand-1
    PHD-1 ligand-1 (Compound 1) is a PHD-1 ligand. PHD-1 ligand-1 serves as a target protein ligand for the synthesis of PHD-1 PROTAC degraders, such as SH-26 (HY-183995). PHD-1 ligand-1 is applicable to studies on ischemia/reperfusion injury.
    PHD-1 ligand-1
  • HY-158433
    KDM5B ligand 2
    KDM5B ligand 2 is the ligand for target protein KDM5B. KDM5B ligand 2 is utilized for synthesis of KDM5B PROTAC GT-653 (HY-158432).
    KDM5B ligand 2
  • HY-179317
    BCL6 ligand-8 3084697-86-6
    BCL6 ligand-8 is a PROTAC target protein ligand that can be used for synthesis of PROTACs, such as BCL6-760 (HY-178777). BCL6-760 is a potent BCL6 PROTAC degrader with anti-tumor activity.
    BCL6 ligand-8
  • HY-174430
    WWQ-131 1558007-80-9
    WWQ-131 is a potent selective JAK2 inhibitor with an IC50 of 2.56 nM. WWQ-131 shows >252-fold selectivity over JAK1, JAK3, and TYK2. WWQ-131 exhibits antiproliferative activity against cancer cells. WWQ-131 is the ligand for target protein for PROTAC JAK2 degrader-1 (HY-174428). WWQ-131 can be used for the research of myeloproliferative neoplasms (MPNs).
    WWQ-131
  • HY-179643
    Aurora-A ligand 2 2677798-57-9
    Aurora-A ligand 2 is a ligand for the target protein of PROTAC. Aurora-A ligand 2 can be used to synthesize SK4454 (HY-179640).
    Aurora-A ligand 2
  • HY-159009
    MS7 1593654-46-6
    MS7 is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). NAMPT is overexpressed in many cancer cells to meet the continuous replenishment of NAD+ required for rapid proliferation. MS7, as a NAMPT target protein ligand, can be used to synthesize PROTAC A7, which is an effective NAMPT degrader. MS7 can be used in cancer research.
    MS7
  • HY-171765
    SMARCA2/4-ligand-6 1997321-77-3
    SMARCA2/4-ligand-6 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-ligand-6 can be used for the synthesis of SMARCA2/4-ligand-6 (HY-156568).
    SMARCA2/4-ligand-6
  • HY-170988
    FKBP12 ligand-1 178446-02-1
    FKBP12 ligand-1 is a targeting protein ligand of MC-25B (HY-170983), which is a specific FKBP12 PROTAC.
    FKBP12 ligand-1
  • HY-111843
    Ch55-O-C3-NH2 144298-98-6
    Ch55-O-C3-NH2 (RAR ligand 1) is a Ch 55-based ligand, which targets RAR. Ch55-O-C3-NH2 (RAR ligand 1) binds to cIAP1 ligand Bestatin via a linker to form SNIPER.
    Ch55-O-C3-NH2
  • HY-170997
    CypA ligand-1
    CypA ligand-1 is the ligand for CypA that can be used as target protein ligand for synthesis of PROTAC degrader PROTAC CG167 (HY-173009).
    CypA ligand-1
  • HY-179434
    HIF-1α-IN-10 3095636-66-8
    HIF-1α-IN-10 is a ligands for target protein for PROTAC (HIF-1α). HIF-1α-IN-10 can be used to synthesize PROTAC HIF-1α degrader-2 (HY-179424).
    HIF-1α-IN-10